Sedating antihistamines side effects stories dating
Wide distribution occurs in body tissues including lungs, heart, brain, and liver.
Renal disease, genetic factors, age, and other medications affect the metabolism and subsequent elimination of doxepin.
Therefore, MAO inhibitors should be discontinued at least two weeks prior to the cautious initiation of therapy with Zonalon Cream.
The exact length of time may vary and is dependent upon the particular MAO inhibitor being used, the length of time it has been administered, and the dosage involved.
Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Doxepin is excreted in human milk after oral administration.
It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6.
Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug.
Alcohol Alcohol ingestion may exacerbate the potential sedative effects of Zonalon Cream.
This is especially important in patients who may use alcohol excessively.
(doxepin hydrochloride) Cream, 5% is a topical cream.
Each gram contains: 50 mg of doxepin hydrochloride (equivalent to 44.3 mg of doxepin).
Patients should also be cautioned that their response to alcohol may be potentiated.